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Publications

2026

Wolfe, S., Nayaz, T., Janiga-MacNelly, A., Fernandez-Luna, M.T., and Lavado, R. Structure-dependent cytotoxicity of environmentally relevant benzothiazole derivatives across human cell models. International Journal of Toxicology. In Press (2026). DOI:10.1177/10915818261475244.

Janiga-MacNelly, A.M., Barrick, A., Hoang, T.C., and Lavado, R. From consumer plastics to aquatic toxicants: oxidative and endocrine effects of microplastics on fathead minnow (Pimephales promelas) larvae. Environmental Toxicology. In Press (2026). DOI: 10.1002/tox.70160.

Rifa, R.A., and Lavado, R. Bisphenol analog-induced cytotoxicity: unraveling endoplasmic reticulum (ER) stress and apoptotic pathways. Journal of Applied Toxicology. In Press (2026). DOI: 10.1002/jat.70248.

Scano, C., Choudhury, A., Rojo, M.G., Hawkins, J., Crowhurst, L., Zaharas, G., Lavado, R., and Greathouse, L. Clinical isolates of Fusobacterium nucleatum display strain-specific virulence and modulation by indole derivatives. Microbiology 172 (2026), 001729.

DiBona, E.R., Elliott, J., Labeille, R.O., Lavado, R., Abdullah, H. and Seeman, F. Stage-specific disruption of host resistance and metabolic pathways following developmental PFAS exposure in marine medaka. Aquatic Toxicology 298 (2026), 107902.

Bradley, C., and Lavado, R. Cellular toxicity assessment of common plasticizers: Implications for musculoskeletal and cardiovascular health. Toxicology in Vitro 115 (2026), 106250.

2025

Collier, G.E., and Lavado, R. Functional and transcriptional disruption of hepatic ABC transporters by environmentally relevant short-chain per- and polyfluoroalkyl substances (PFAS). Journal of Biochemical and Molecular Toxicology 39 (2025), e70659.

Collier, G.E., and Lavado, R. Visualization-based evaluation of short-chain PFAS effects on ABCG2 in human cell models: A preliminary study. Next Research 2 (2025), 101083.

Rifa, R.A., Rojo, M., and Lavado, R. Mechanisms of toxicity caused by bisphenol analogs in human in vitro cell models. Chemico-Biological Interactions 412 (2025), 111475.

Janiga-MacNelly, A., McGraw, M., Fernandez-Luna, M.T., and Lavado, R. Assessment of the toxic effects of parabens, commonly used preservatives in cosmetics, and their halogenated by-products on human skin and endothelial cells. NAM Journal 1 (2025), 100011.

Janiga-MacNelly, A., Vrazel, M., Roat, A.E., Fernandez-Luna, M.T., and Lavado, R. Exploring the biological impact of bacteria-derived indole compounds on human cell health: cytotoxicity and cell proliferation across six cell lines. Toxicology Reports 14 (2025), 101883.

Janiga-MacNelly, A., Hoang, T.C., and Lavado, R. Comparative toxicity of microplastics obtained from human consumer products on human cell-based models. Food and Chemical Toxicology 196 (2025), 115194.

2024

Rifa, R.A., and Lavado, R. Cytotoxic impacts of seven alternative bisphenols on human in vitro cellular models. Chemosphere 366 (2024), 143408.

Janiga-MacNelly, A., and Lavado, R. Unveiling the mysteries: a deep dive into extracellular polymeric substances in activated sludge systems of wastewater treatment plants. Environmental Technology Reviews 13 (2024), 572-596.

Rojo, M., Ball, A.L., Penrose, M.T., Weir, S.M., LeBaron, H., Terasaki, M., Cobb, G.P., and Lavado, R. Accumulation of parabens, their metabolites, and halogenated byproducts in migratory birds of prey: a comparative study in Texas and North Carolina, USA. Environmental Toxicology and Chemistry 43 (2024), 2365-2376.

Collier, G.E., and Lavado, R. An in-depth examination of per- and polyfluoroalkyl (PFAS) effects on transporters, with emphasis on the ABC superfamily: a critical review. Toxicology 508 (2024), 153901.

Senthilkumar, S., Solan, M.E., Fernandez-Luna, M., and Lavado, R. Cannabidiol and indole-3-carbinol reduce intracellular lipid droplet accumulation in HepaRG, a human liver cell line, as well as in human adipocytes. The Natural Products Journal 14 (2024), e260523217374.

2023

Rifa, R.A., and Lavado, R. Unveiling the next generation of bisphenol analogs and their impact on human health using in vitro methods. Emerging Contaminants 10 (2023), 100296.

Solan, M.E., Schackmuth, B., Bruce, E., Pradhan, S., Sayes, C., and Lavado, R. Effects of short-chain per- and polyfluoroalkyl substances (PFAS) on toxicologically relevant gene expression profiles in a liver-on-a-chip model. Environmental Pollution 337 (2023), 122610.

Cumming, R.T., Le Tirant, S., Linde, J.B., Solan, M.E., Foley, E.M., Eulin, N.E., Lavado, R., Whiting, M.F., Bradler, S., and Bank, S. On seven undescribed leaf insect species revealed within the recent “Tree of Leaves” (Phasmatodea, Phylliidae). Zookeys 1173 (2023), 145-229.

Solan, M.E., and Lavado, R. Effects of short-chain per- and polyfluoroalkyl substances (PFAS) on human cytochrome P450 (CYP450) enzymes and human hepatocytes: an in vitro study. Current Research in Toxicology 5 (2023), 100116.

Aquino, G.V., Dabi, A., Odom, G.J., Lavado, R., Nunn, K., Thomas, K., Schackmuth, B., Shariff, N., Jarajapu, M., Pluto, M., Miller, S.R., Eller, L., Pressley, J., Patel, R.R., Black, J., and Bruce, E. Evaluating the effect of acute diesel exhaust particle exposure on P-glycoprotein efflux transporter in the blood-brain barrier co-cultured with microglia. Current Research in Toxicology 4 (2023), 100107.

Solan, M.E., Koperski, C.P., Senthilkumar, S., and Lavado, R. Short-chain per- and polyfluoralkyl substances (PFAS) effects on oxidative stress biomarkers in human liver, kidney, muscle, and microglia cell lines. Environmental Research 223 (2023), 115424.

Ball, A.L., Solan, M.E., Franco, M.E., and Lavado, R. Comparative cytotoxicity induced by parabens and their halogenated byproducts in human and fish cell lines. Drug and Chemical Toxicology 46 (2023), 786-794.

2022

Solan, M.E., Senthilkumar, S., Aquino, G.V., Bruce, E.D., and Lavado, R. Comparative cytotoxicity of seven per-and polyfluoroalkyl substances (PFAS) in six human cell lines. Toxicology 477 (2022), 153281.

Solan, M.E., Franco, M.E., and Lavado, R. Effects of perfluoroalkyl substances (PFASs) and benzo[a]pyrene (BaP) co-exposure on phase I biotransformation in rainbow trout (Oncorhynchus mykiss). Fish Physiology and Biochemistry 48 (2022), 925-935.

Solan, M.E., and Lavado, R. The use of in vitro methods in assessing human health risks associated with short‐chain perfluoroalkyl and polyfluoroalkyl substances (PFAS). Journal of Applied Toxicology 42 (2022), 1298-1309.

Franco, M.E., Ramirez, A.J., Johanning, K.M., Matson, C., and Lavado, R. In vitro-in vivo biotransformation and phase I metabolite profiling of benzo[a]pyrene in Gulf killifish (Fundulus grandis) populations with different exposure histories. Aquatic Toxicology 243 (2022), 106057.

Franco, M.E., Johanning, K., Matson, C.W., and Lavado, R. Reduced biotransformation of polycyclic aromatic hydrocarbons (PAHs) in pollution-adapted Gulf killifish (Fundulus grandis). Science of the Total Environment 806 (2022), 150854.

Ismaeel, A., Lavado, R., and Koutakis, P. Metabolomics of peripheral artery disease. Advances in Clinical Chemistry 106 (2022), 67-89.

2021

Ball, A.L., and Lavado, R. Ecotoxicology assessments in avian species using cell-based models: A review. Avian Biology Research (2019), 17581559211030850.

Franco, M.E., Dhungana, B., Patel, K., Krahenbuhl, V., Abel, M., Martin, G.D., Cobb, G.P., and Lavado, R. Seasonal characterization of bacterial communities in industrial wastewater and their relationship with flocculation indices and extracellular polymeric substances. Environmental Science and Technology Water 1 (2021), 1411–1419.

2020

Franco, M.E., Stroski, K.M., Sims, J.L., Burket, S.R., Ashcroft, C., Luers, M., Brooks, N.W., and Lavado, R. Plasma vitellogenin reveals potential seasonal estrogenicity in fish from on-site wastewater treatment systems in semi-arid streams influenced by snowmelt. Bulletin of Environmental Contamination and Toxicology 105 (2020), 692-698.

Franco, M.E., Burket, S.R, Sims, J.L., Lovin, L.M., Scarlett, K.R., Stroski, K., Steenbeek, R., Ashcroft, C., Luers, M., Brooks, B.W., and Lavado, R. Multi-approach assessment for the evaluation of spatio-temporal estrogenicity in fish from effluent-dominated surface waters under low instream flow. Environmental Pollution 265B (2020), 115122.

Franco, M.E., Fernandez-Luna, M.T., Ramirez, A.J., and Lavado, R. Metabolomic-based assessment reveals dysregulation of lipid profiles in human liver cells exposed to environmental obesogens. Toxicology and Applied Pharmacology 398, (2020), 115009.

Sims, J.L., Burket, S.R., Franco, M.E., Lovin, L.M., Scarlett, K.R., Steenbeek, R., Chambliss, C.K., Ashcroft, C., Luers, M., Lavado, R., and Brooks, B.W. Pharmaceutical uptake kinetics in rainbow trout: In situ bioaccumulation in an effluent-dominated river influenced by snowmelt. Science of the Total Environment 736 (2020), 139603.

Franco, M.E., Sutherland, G.E., Fernandez-Luna, M.T., and Lavado, R. Altered expression of phase I and II biotransformation enzymes in human liver cells by perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS). Toxicology 430 (2020), 152339.

Ismaeel, A., Papoutsi, E., Miserlis, D., Lavado, R., Haynatzki, G., Casale, G.P., Bohannon, W.T., Smith, R.S., Eidson, J.L., Brumberg, R., Hayson, A., Kirk, J.S., Castro, C., Sawicki, I., Konstantinout, C., Brewster, L.P., Pipinos, I.I. and Koutakis, P. The nitric oxide system in peripheral artery disease: connection with oxidative stress and biopterins. Antioxidants 9 (2020), 590.

Sutherland, G.E., Franco, M.E., Matson, C.W., and Lavado, R. Oxidative potential of chemical mixtures extracted from contaminated Galveston Bay, TX seafood using a human cell co-culture model. Archives of Environmental Contamination and Toxicology 78 (2020), 149-162.

2019

Ishmaeel, A., Franco, M.E., Lavado, R., Papoutsi, E., Casale, G.P., Fuglestad, M., Mietus, C.J., Haynatzki, G.R., Smith, R.S., Bohannon, W.T., Sawicki, I., Pipinos, I.I., and Koutakis, P. Altered metabolomic profile in patients with peripheral artery disease. Journal of Clinical Medicine 8 (2019), 1463.

Franco, M.E., Hill, B.N., Brooks, B.W., and Lavado, R. Prymnesium parvum differentially triggers sublethal fish antioxidant responses in vitro among salinity and nutrient conditions. Aquatic Toxicology 213 (2019), 105214.

Franco, M.E., and Lavado, R. Applicability of in vitro models in evaluating the biotransformation of polycyclic aromatic hydrocarbons (PAHs) in fish: advances and challenges. Science of the Total Environment 671 (2019), 685-695.

Sutherland, G.E., Franco, M.E., Willing, S.M., and Lavado, R. Applicability of a human cell co-culture model to evaluate antioxidant responses triggered by chemical mixtures in fish and oyster homogenates. Food and Chemical Toxicology 128 (2019), 154-162.

2018

Ishmaeel, A., Lavado, R., Smith, R.S., Eidon, J.L., Sawicki, I., Kirk, J.S., Bohannon, W.T. and Koutakis, P. Effects of limb revascularization procedures on oxidative stress. Journal of Surgical Research 232 (2018), 503-509.

Franco, M.E., Sutherland, G.E. and Lavado, R. Xenobiotic metabolism in the fish hepatic cell lines Hepa-E1 and RTH-149, and the gill cell lines RTgill-W1 and G1B: biomarkers of CYP450 activity and oxidative stress. Comparative Biochemistry and Physiology Part C: Toxicology and Pharmacology 206-207 (2018), 32-40.

2017

Oziolor, E.M., Howard, W., Lavado, R., and Matson, C.W. Induced pesticide tolerance results from detoxification pathway priming. Environmental Pollution 224 (2017), 615-621.

2016

Maldonado, A., Lavado, R., Knutson, S., Slattery, M., Goldstone, J.V., Watanabe, K., Hoh, E., Gadepalli, R.S., Rimoldi, J.M., Ostrander, G.K., and Schlenk, D. Biochemical mechanisms for geographical adaptations to novel toxin exposures in butterflyfish. PLOS One 11 (2016), e0154208.

2015

Maryoung, L., Lavado, R., Bammler, T., Gallagher, E., Stapleton, P., Beyer, R., Farin, F., Hardiman, G., and Schlenk, D. Differential gene expression in liver, gill and olfactory rosettes of coho salmon (Oncorhynchus kisutch) after acclimation to salinity. Marine Biotechnology 17 (2015), 703-717.

Crago, J., Tran, K., Budicin, A., Schreiber, B., Lavado, R., and Schlenk, D. Exploring the impacts of two separate mixtures of pesticide and surfactants on estrogenic activity in male fathead minnows and rainbow trout. Archives of Environmental Contamination and Toxicology 68 (2015), 362-370.

2014

Maryoung, L.A., Lavado, R., and Schlenk, D. Impacts of hypersaline acclimation on the acute toxicity of the organophosphate chlorpyrifos to salmonids. Aquatic Toxicology 152 (2014), 284-290.

Lyons, K., Lavado, R., Schlenk, D., and Lowe, C. Bioaccumulation of organochlorine contaminants and EROD activity in southern California round stingrays (Urobatis halleri) exposed to planar aromatic compounds. Environmental Toxicology and Chemistry 33 (2014), 1380-1390.

Forsgren, K.L., Qu, S., Lavado, R., Cwiertny, D., and Schlenk, D. Trenbolone acetate metabolites promote ovarian growth and development in adult Japanese medaka (Oryzias latipes). General and Comparative Endocrinology 202 (2014), 1-7.

Lavado, R., Li, J., Rimoldi, J.M., and Schlenk, D. Evaluation of the stereoselective biotransformation of permethrin in human liver microsomes: contributions of cytochrome P450 monooxygenases to the formation of estrogenic metabolites. Toxicology Letters 226 (2014), 192-197.

Lavado, R., Aparicio-Fabre, R., and Schlenk, D. Effects of salinity acclimation on the expression and activity of Phase I enzymes (CYP450 and FMOs) in coho salmon (Oncorhynchus kisutch). Fish Physiology and Biochemistry 40 (2014), 267-278.

2013

Lavado, R., Aparicio-Fabre, R., and Schlenk, D. Effects of salinity acclimation on the pesticide-metabolizing enzyme flavin-containing monooxygenase (FMO) in rainbow trout (Oncorhynchus mykiss). Comparative Biochemistry and Physiology Part C: Toxicology and Pharmacology 157 (2013), 9-15.

2012

Schlenk, D., Lavado, R., Loyo-Rosales, J.E., Jones, W., Maryoung, L., Riar, N., Werner, I., and Sedlak, D. Reconstitution studies of pesticides and surfactants exploring the cause of estrogenic activity observed in surface waters of the San Francisco Bay Delta. Environmental Science and Technology 46 (2012), 9106-9111.

Bulloch, D., Lavado, R., Forsgren, K.L., Szabolcs, B., Schlenk, D., and Larive, C.K. Analytical and biological characterization of halogenated gemfibrozil produced through chlorination of wastewater. Environmental Science and Technology 46 (2012), 5583-5589.

Lavado, R., Shi, D., and Schlenk, D. Effects of salinity on the toxicity and biotransformation of L-selenomethionine in Japanese medaka (Oryzias latipes) embryos: mechanisms of oxidative stress. Aquatic Toxicology 108 (2012), 18-22.

2011

Schlenk, D., and Lavado, R. Impacts of climate change on hypersaline conditions of estuaries and xenobiotic toxicity. Aquatic Toxicology S105 (2011), 78-82.

Lavado, R., Maryoung, L.A., and Schlenk, D. Hypersaline acclimation increases the toxicity of the insecticide phorate in coho salmon (Oncorhynchus kisutch). Environmental Science and Technology 45 (2011), 4623-4629.

Lavado, R., and Schlenk, D. Microsomal biotransformation of chlorpyrifos, parathion and fenthion in rainbow trout (Oncorhynchus mykiss) and coho salmon (Oncorhynchus kisutch): Mechanistic insights into interspecific differences in toxicity. Aquatic Toxicology 101 (2011), 57-63.

2010

Nillos, M.G., Chajkowski, S., Rimoldi, J.M., Gan, J., Lavado, R., and Schlenk, D. Stereoselective biotransformation of permethrin to estrogenic metabolites in fish. Chemical Research in Toxicology 23 (2010), 1568-1575.

Bulloch, D., Lavado, R., and Schlenk, D. Bioassay-guided fractionation (Toxicity Identification and Evaluation) for the determination of estrogenic agents in environmental samples. In: Contaminants of Emerging Concern in the Environment: Ecological and Human Health Considerations. ACS Symposium Series Volume 1048 (2010), ACS Press. Chapter 26, pp 519-537.

2009

Lavado, R., Loyo-Rosales, J.E., Floyd, E., Kolodziej, E.P., Snyder, S.A., Sedlak, D.L., and Schlenk, D. Site-specific profiles of estrogenic activity in agricultural areas of California’s inland waters. Environmental Science and Technology 43 (2009), 9110-9116.

Barbaglio, A., Biressi, A., Melone, G., Bonasoro, F., Lavado, R., Porte, C., and Candia Carnevali, M.D. Reproductive cycle of Antedon mediterranea (Crinoidea, Echinodermata): correlation between morphology and physiology. Zoomorphology 128 (2009), 119-134.

Lavado, R., Rimoldi, J.M., and Schlenk, D. Mechanisms of fenthion activation in rainbow trout (Oncorhynchus mykiss) acclimated to hypersaline environments. Toxicology and Applied Pharmacology 235 (2009), 143-152.

Coronado, M., De Haro, H., Deng, X., Rempel, M.A., Lavado, R., and Schlenk, D. Estrogenic activity and reproductive effects of the UV-filter oxybenzone (2-hydroxy-4-methoxyl-methanone) in fish. Aquatic Toxicology 90 (2008), 182-187.

2008

Matsuo, A.Y.O., Gallagher, E.P., Trute, M., Stapleton, P.L., Lavado, R., and Schlenk, D. Characterization of phase I biotransformation enzymes in coho salmon (Oncorhynchus kisutch). Comparative Biochemistry and Physiology Part C: Toxicology and Pharmacology 147 (2008), 78-84.

2007

Barbaglio, A., Sugni, M., Di Benedetto, C., Bonasoro, F., Schnell, S., Lavado, R., Porte, C., and Candia Carnevali, M.D. Gametogenesis correlated with steroid levels during the gonadal cycle of the sea urchin Paracentrotus lividus (Echinodermata: Echinoidea). Comparative Biochemistry and Physiology Part A: Molecular and Integrative Physiology 147 (2007), 466-474.

2006

Lavado, R., Sugni, M., Candia Carnevali, M.D., and Porte, C. Triphenyltin alters androgen metabolism in the sea urchin Paracentrotus lividus. Aquatic Toxicology 79 (2006), 247-256.

Lavado, R., Janer, G., and Porte, C. Steroid levels and steroid metabolism in the mussel Mytilus edulis: the modulating effect of dispersed crude oil and alkylphenols. Aquatic Toxicology S78 (2006), 65-72.

Lavado, R., Barbaglio, A., Candia Carnevali, M.D., and Porte, C. Steroid levels in crinoid echinoderms are altered by exposure to model endocrine disruptors. Steroids 71 (2006), 489-497.

Martin-Skilton, R., Lavado, R., Thibaut, R., and Porte, C. Evidence of endocrine alteration in the red mullet, Mullus barbatus, from the NW Mediterranean. Environmental Pollution 141 (2006), 60-68.

Barbaglio, A., Mozzi, D., Sugni, M., Tremolada, P., Lavado, R., Porte, C., and Candia Carnevali, M.D. Effects of exposure to ED contaminants (TPT-Cl and Fenarimol) on crinoid echinoderms: comparative analysis of regenerative development and correlated steroid levels. Marine Biology 149 (2006), 65-77.

Schulte-Oehlmann, U., Albanis, T., Allera, A., Bachmann, J., Berntsson, P., Beresford, N., Candia Carnevali, C., Ciceri, F., Dagnac, T., Falandysz, J., Galassi, S., Hala, D., Janer, G., Jeannot, R., Jobling, S., King, I., Klingmüller, D., Kloas, W., Ole Kusk, K., Lavado, R., Lo, S., Lutz, I., Oehlmann, J., Oredsson, S., Porte, C., Rand-Weaver, M., Sakkas, V., Sugni, M., Tyler, C., van Aerle, R., van Ballegoy, C., and Wollenberger, L. COMPRENDO: Focus and Approach. Environmental Health Perspectives 114 (2006), 98-100.

Lavado, R., Ureña, R., Martín-Skilton, R., Torreblanca, A., del Ramo, J., Raldúa, D., and Porte, C. The combined use of chemical and biochemical markers to assess water quality along the Ebro River. Environmental Pollution 139 (2006), 330-339.

2005

Janer, G., Lavado, R., Thibaut, R., and Porte, C. Effects of 17beta estradiol exposure in the mussel Mytilus galloprovincialis: a possible regulating role for steroid acyltransferases. Aquatic Toxicology 75 (2005), 32-42.

2004

Lavado, R., Raldua, D., Thibaut, R., Martin, R., and Porte, C. First evidence of endocrine disruption in feral carp from the Ebro River. Toxicology and Applied Pharmacology 196 (2004), 247-257.

Janer, G., Lavado, R., Thibaut, R., and Porte, C. Effects of 17beta estradiol exposure in the mussel Mytilus galloprovincialis. Marine Environmental Research 58 (2004), 443-446.

2002

Fernandes, D., Potrykus, J., Morsiani, C., Raldua, D., Lavado, R., and Porte, C. The combined use of chemical and biochemical markers to assess water quality in two low-stream rivers (NE Spain). Environmental Research Section A 90 (2002), 169-178.

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